Human rhinovirus infection induces local and systemic immunological tolerance in healthy volunteers

Human rhinovirus infection induces local and systemic immunological tolerance in healthy volunteers

Introduction A large proportion of ICU patients suffer from respiratory virus infections. This is often complicated by secondary infections, suggesting increased vulnerability in these patients. Recent work has shown that in bacterial sepsis, a immunosuppressive state called “immunoparalysis” accounts for this increased vulnerability. However, virus-induced immunoparalysis is largely unstudied....

Experimental rhinovirus infection in volunteers.

Experimental viral disease studies in volunteers have clarified many aspects of the pathogenesis of human viral disease. Recently, interest has focused on rhinovirus-associated asthma exacerbations, and new volunteer studies have suggested that airway responsiveness (AR) is enhanced during a cold. For scientific, ethical and safety reasons, it is important to use validated methods for the prepa...

Epithelial Cell Production of Human Human Rhinovirus Infection Induces Airway

Rhinovirus infection induces mucus hypersecretion.

Rhinorrhea is a prominent symptom of the common cold. Although increases in vascular permeability and serous cell secretion have been demonstrated in human nasal mucus during active rhinovirus infections, changes in mucin constituents have not been quantified. Nonallergic ( n= 48) and asymptomatic allergic rhinitis ( n = 32) subjects were inoculated with rhinovirus type hanks before the spring ...

Breaking Immunological Tolerance in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease of unknown etiology that mainly affects women in the childbearing age. SLE is a prototype type III hypersensitivity reaction in which immune complex depositions cause inflammation and tissue damage in multiple organs. Two distinct cell death pathways, apoptosis and NETosis, gained a great deal of interest among scie...